BDBM50323343 6-(4-Chloro-benzyl)-4-isobutyl-6,7-dihydro-5-thia-2,3a,6-triaza-indene 5,5-dioxide::CHEMBL1209553

SMILES CC(C)CC1n2cncc2CN(Cc2ccc(Cl)cc2)S1(=O)=O

InChI Key InChIKey=SLIFTHAOQMHZDP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323343   

TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323343(6-(4-Chloro-benzyl)-4-isobutyl-6,7-dihydro-5-thia-...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323343(6-(4-Chloro-benzyl)-4-isobutyl-6,7-dihydro-5-thia-...)
Affinity DataIC50:  87nMAssay Description:Inhibition of human CYP3A4-mediated testosterone oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323343(6-(4-Chloro-benzyl)-4-isobutyl-6,7-dihydro-5-thia-...)
Affinity DataIC50:  50.2nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed