BDBM50324575 (R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxamide::CHEMBL1215171

SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1

InChI Key InChIKey=JPIZMTCZKMZLDC-JOCHJYFZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50324575   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324575((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...)
Affinity DataIC50:  51nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324575((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324575((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...)
Affinity DataIC50:  5.35E+3nMAssay Description:Inhibition of MRCKalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324575((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...)
Affinity DataIC50:  48nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed