BDBM50327090 1-(1-tert-Butyl-1H-pyrazol-4-yl)-3-{2-chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}urea::CHEMBL1254356::D3RKN_22

SMILES Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cnn(c4)C(C)(C)C)c(Cl)c3)c12

InChI Key InChIKey=KPILPRJNCZJVNG-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327090   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50327090(1-(1-tert-Butyl-1H-pyrazol-4-yl)-3-{2-chloro-4-[(5...)
Affinity DataIC50:  940nMAssay Description:Inhibition of His-tagged human FGFR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50327090(1-(1-tert-Butyl-1H-pyrazol-4-yl)-3-{2-chloro-4-[(5...)
Affinity DataKd:  710nMAssay Description:D3R2023More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50327090(1-(1-tert-Butyl-1H-pyrazol-4-yl)-3-{2-chloro-4-[(5...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2022More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50327090(1-(1-tert-Butyl-1H-pyrazol-4-yl)-3-{2-chloro-4-[(5...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of His-tagged human VEGFR2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed