BDBM50327667 CHEMBL1084637::Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Methyl Ester::methyl dibenzo[b,f][1,4]oxazepine-4-carboxylate

SMILES COC(=O)c1cccc2C=Nc3ccccc3Oc12

InChI Key InChIKey=SDVPFOUQQWZGMJ-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50327667   

TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(CHEMBL1084637 | Dibenzo[b,f][1,4]oxazepine-4-carbo...)
Affinity DataEC50:  83nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -30 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(CHEMBL1084637 | Dibenzo[b,f][1,4]oxazepine-4-carbo...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at 75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(CHEMBL1084637 | Dibenzo[b,f][1,4]oxazepine-4-carbo...)
Affinity DataEC50:  0.0603nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(CHEMBL1084637 | Dibenzo[b,f][1,4]oxazepine-4-carbo...)
Affinity DataEC50:  7.40nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as time point of maximal current amplitude by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(CHEMBL1084637 | Dibenzo[b,f][1,4]oxazepine-4-carbo...)
Affinity DataEC50:  83.2nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -30 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50327667(CHEMBL1084637 | Dibenzo[b,f][1,4]oxazepine-4-carbo...)
Affinity DataEC50:  126nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells at -75 mV holding potential by patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed