BDBM50327847 1-(1-(Trifluoroacetyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea::CHEMBL1257517::US8501783, 1591::US9296693, 53

SMILES FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)C(=O)C(F)(F)F)cc1

InChI Key InChIKey=HAMLMZMEEHRTDE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50327847   

TargetEpoxide hydrolase 1(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM50327847(1-(1-(Trifluoroacetyl)piperidin-4-yl)-3-(4-(triflu...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition assay of human soluble epoxide hydrolases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM50327847(1-(1-(Trifluoroacetyl)piperidin-4-yl)-3-(4-(triflu...)
Affinity DataIC50:  0.400nMpH: 7.0Assay Description:IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Department Of Entomology And University Of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM50327847(1-(1-(Trifluoroacetyl)piperidin-4-yl)-3-(4-(triflu...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of mouse recombinant soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM50327847(1-(1-(Trifluoroacetyl)piperidin-4-yl)-3-(4-(triflu...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Department Of Entomology And University Of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM50327847(1-(1-(Trifluoroacetyl)piperidin-4-yl)-3-(4-(triflu...)
Affinity DataIC50:  0.400nMpH: 7.0Assay Description:IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-...More data for this Ligand-Target Pair
In DepthDetails US Patent