BDBM50327850 1-(1-Tosylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea::CHEMBL1257759::US8501783, 1711::US9296693, 58

SMILES Cc1ccc(cc1)S(=O)(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=CLIYCAVTAMNXLB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50327850   

TargetEpoxide hydrolase 1(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM50327850(1-(1-Tosylpiperidin-4-yl)-3-(4-(trifluoromethoxy)p...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition assay of human soluble epoxide hydrolases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM50327850(1-(1-Tosylpiperidin-4-yl)-3-(4-(trifluoromethoxy)p...)
Affinity DataIC50:  0.400nMpH: 7.0Assay Description:IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Department Of Entomology And University Of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM50327850(1-(1-Tosylpiperidin-4-yl)-3-(4-(trifluoromethoxy)p...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of mouse recombinant soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM50327850(1-(1-Tosylpiperidin-4-yl)-3-(4-(trifluoromethoxy)p...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Department Of Entomology And University Of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM50327850(1-(1-Tosylpiperidin-4-yl)-3-(4-(trifluoromethoxy)p...)
Affinity DataIC50:  0.400nMpH: 7.0Assay Description:IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-...More data for this Ligand-Target Pair
In DepthDetails US Patent