BDBM50328817 CHEMBL1270460::N-(3-Fluorophenethyl)-2-((3R,4R)-4-((6-iminopiperidin-2-yl)methyl)pyrrolidin-3-yloxy)ethanamine

SMILES NC1=NC(C[C@@H]2CNC[C@@H]2OCCNCCc2cccc(F)c2)CCC1

InChI Key InChIKey=HZHJCKDWMOAWJH-WDOSNPKHSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50328817   

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50328817(CHEMBL1270460 | N-(3-Fluorophenethyl)-2-((3R,4R)-4...)
Affinity DataKi:  110nMAssay Description:Inhibition of rat nNOS expressed in Escherichia coli assessed as inhibition of nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50328817(CHEMBL1270460 | N-(3-Fluorophenethyl)-2-((3R,4R)-4...)
Affinity DataKi:  490nMAssay Description:Inhibition of human nNOS expressed in Escherichia coli assessed as inhibition of nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50328817(CHEMBL1270460 | N-(3-Fluorophenethyl)-2-((3R,4R)-4...)
Affinity DataKi:  2.18E+4nMAssay Description:Inhibition of mouse iNOS expressed in Escherichia coli assessed as inhibition of nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50328817(CHEMBL1270460 | N-(3-Fluorophenethyl)-2-((3R,4R)-4...)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of bovine eNOS expressed in Escherichia coli assessed as inhibition of nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed