BDBM50329070 CHEMBL1269858::N2-(3,5-dimorpholinophenyl)-N4-(1H-indazol-4-yl)-N4-methylpyrimidine-2,4-diamine

SMILES CN(c1ccnc(Nc2cc(cc(c2)N2CCOCC2)N2CCOCC2)n1)c1cccc2[nH]ncc12

InChI Key InChIKey=QLFGDTPACJHLRY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50329070   

TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  9nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  240nMAssay Description:Inhibition of KDR phosphorylation in HUVECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  58nMAssay Description:Inhibition of PDGFRbeta phosphorylation in human MG63 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed