BDBM50329657 6-Ethynl-9H-beta-carboline-3-carboxylic acid t-butyl ester::CHEMBL1270038

SMILES CC(C)(C)OC(=O)c1cc2c(cn1)[nH]c1ccc(cc21)C#C

InChI Key InChIKey=NPBFSLFGBCAWAF-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50329657   

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  0.972nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha1beta3gamma2 receptor expressed in HEK cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human recombinant GABAA alpha1 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  100nMAssay Description:Binding affinity to human recombinant GABAA alpha3 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha3beta3gamma2 receptor expressed in HEK cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  110nMAssay Description:Binding affinity to human recombinant GABAA alpha2 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  111nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha2beta3gamma2 receptor expressed in HEK cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  208nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha5beta3gamma2 receptor expressed in HEK cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  210nMAssay Description:Binding affinity to human recombinant GABAA alpha5 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  1.98E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha6beta3gamma2 receptor expressed in HEK cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha4 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGABA A receptor alpha-4/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha4beta3gamma2 receptor expressed in HEK cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50329657(6-Ethynl-9H-beta-carboline-3-carboxylic acid t-but...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha6 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed