BDBM50330262 CHEMBL1272171::N*6'*-[4-(5-Isopropyl-3-trifluoromethyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-N*4*,N*4*-dimethyl-3,4,5,6-tetrahydro-2H-[1,3']-bipyridinyl-4,6'-diamine

SMILES CC(C)c1[nH]nc(c1-c1ccnc(Nc2ccc(cn2)N2CCC(CC2)N(C)C)n1)C(F)(F)F

InChI Key InChIKey=DBZXYASRLGQZEQ-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50330262   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human CDK4/cyclin D1 expressed in baculovirus infected Sf21 cells after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine--tRNA ligase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human CDK2/cyclin A after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50:  557nMAssay Description:Inhibition of CDK4 in human Jeko1 cells assessed as phosphorylated pRb at Ser780 level after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKBalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of human CDK1/cyclin B after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330262(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Affinity DataIC50:  468nMAssay Description:Inhibition of CDK4 in human Jeko1 cells assessed as phosphorylated pRb at Ser780 level after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed