BDBM50330267 4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine::CHEMBL1230170::[4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-(5-piperazin-1-yl-pyridin-2-yl)-amine

SMILES CC(C)c1n[nH]c(Cl)c1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1

InChI Key InChIKey=ZGJLAVYYTJNBMN-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50330267   

TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330267(4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of human CDK2/cyclin A after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330267(4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human CDK4/cyclin D1 expressed in baculovirus infected Sf21 cells after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330267(4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(...)
Affinity DataIC50:  467nMAssay Description:Inhibition of CDK4 in human Jeko1 cells assessed as phosphorylated pRb at Ser780 level after 2 hrs by ELISA relative to total pRb levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50330267(4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(...)
Affinity DataIC50:  6.33E+3nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50330267(4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(...)
Affinity DataIC50:  6.33E+3nMAssay Description:Inhibition of human CDK1/cyclin B after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50330267(4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330267(4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(...)
Affinity DataIC50:  223nMAssay Description:Inhibition of CDK4 in human Jeko1 cells assessed as phosphorylated pRb at Ser780 level after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed