BDBM503309 6-amino-2-[(1R)-1-amino-3,3- difluoro-8-azaspiro[4.5]-decan-8- yl]-5-(2,3-dichloro-phenyl)- pyrimidine-4-carboxamide::US11033547, Compound 8::US11696916, Compound 8

SMILES N[C@@H]1CC(F)(F)CC11CCN(CC1)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O

InChI Key InChIKey=HUMLLBWKKNGQOY-GFCCVEGCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503309   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503309(6-amino-2-[(1R)-1-amino-3,3- difluoro-8-azaspiro[4...)
Affinity DataIC50:  200nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503309(6-amino-2-[(1R)-1-amino-3,3- difluoro-8-azaspiro[4...)
Affinity DataIC50:  200nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent