BDBM50331094 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide::4-(3-chloro-4-(N'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide::CHEMBL1289601::E-7080::Lenvatinib mesilate::Lenvima::US11912663, Compound Lenvatinib::US12071408, Example Lenvatinib::lenvatinib

SMILES COc1cc2c(cc1C(=O)N)c(ccn2)Oc3ccc(c(c3)Cl)NC(=O)NC4CC4

InChI Key InChIKey=WOSKHXYHFSIKNG-UHFFFAOYSA-N

Data  4 KI  39 IC50  2 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 47 hits for monomerid = 50331094   

TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human N-terminal GST-tagged VEGFR2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system using Ulight-JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to full length human recombinant RET assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetFibroblast growth factor receptor 4(Human)
Skyrun Pharma Co.

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of FGFR4 (unknown origin) incubated for 10 mins followed by substrate addition measured after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to VEGFR2 (unknown origin) by proteros reporter displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 3.20nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant VEGFR2 (805 to 1356 residues) in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 5.10nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 6.40nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 7.5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 7.5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 7.5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 7.5nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 11nMAssay Description:Inhibition of FGFR2 (unknown origin) incubated for 10 mins followed by substrate addition measured after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 13nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 22nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 22nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 22nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 27nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 27nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 35nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 39nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 51nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 56nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 59nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Skyrun Pharma Co.

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 65nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 66nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 10 mins followed by substrate addition measured after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 5A, mitochondrial(Human)
"Magna Gr£Cia" University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataKi:  133nMAssay Description:Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Skyrun Pharma Co.

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 311nMAssay Description:Inhibition of FGFR4 (unknown origin) incubated for 10 mins followed by substrate addition measured after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 500nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 1.00E+3nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 1.00E+3nMAssay Description:1. Buffer configuration: 50 mM HEPES, pH 7.5, 0.00015% Brij-35.2. Compounds were configured in 100% DMSO in a concentration gradient and diluted with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

TargetFerrochelatase, mitochondrial [R115L](Human)
Technical University of Munich

LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataKd:  3.10E+3nMAssay Description:Briefly, 5 mg of a protein mixture of the four cell lines or a single cell line were incubated with compound dilution series in DMSO (3 nM, 10 nM, 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
"Magna Gr£Cia" University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
"Magna Gr£Cia" University of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai AB Pharmatech

US Patent
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 1.19E+4nMAssay Description:Stabilized cells were dropped onto circular slides and placed in a culture dish with a cell density below 50% and incubated overnight. Cells for expe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent