BDBM50331124 2-(piperidin-1-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine::CHEMBL1290255::US9422293, 192::US9738649, Example 192

SMILES FC(F)(F)c1cnc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)cn1

InChI Key InChIKey=DKRCGUPZNPZLJO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331124   

TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331124(2-(piperidin-1-yl)-N-(5-(trifluoromethyl)pyrazin-2...)
Affinity DataIC50:  20nMT: 2°CAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331124(2-(piperidin-1-yl)-N-(5-(trifluoromethyl)pyrazin-2...)
Affinity DataIC50:  70nMT: 2°CAssay Description:The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331124(2-(piperidin-1-yl)-N-(5-(trifluoromethyl)pyrazin-2...)
Affinity DataIC50:  70nMAssay Description:The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331124(2-(piperidin-1-yl)-N-(5-(trifluoromethyl)pyrazin-2...)
Affinity DataIC50:  20nMAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331124(2-(piperidin-1-yl)-N-(5-(trifluoromethyl)pyrazin-2...)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at human recombinant TRPV1 assessed as inhibition of capsaicin-induced in intracellular calcium levels by cell-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed