BDBM50331140 7-(3-chloropyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine::CHEMBL1290035::US9422293, 30::US9738649, Example 30

SMILES FC(F)(F)c1ccc(Nc2ncnc3CCN(CCc23)c2ncccc2Cl)cc1

InChI Key InChIKey=BHSLYPQDMMBFGB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331140   

TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331140(7-(3-chloropyridin-2-yl)-N-(4-(trifluoromethyl)phe...)
Affinity DataIC50:  510nMT: 2°CAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331140(7-(3-chloropyridin-2-yl)-N-(4-(trifluoromethyl)phe...)
Affinity DataIC50:  1.30E+3nMT: 2°CAssay Description:The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331140(7-(3-chloropyridin-2-yl)-N-(4-(trifluoromethyl)phe...)
Affinity DataIC50:  1.30E+3nMAssay Description:The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331140(7-(3-chloropyridin-2-yl)-N-(4-(trifluoromethyl)phe...)
Affinity DataIC50:  510nMAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50331140(7-(3-chloropyridin-2-yl)-N-(4-(trifluoromethyl)phe...)
Affinity DataIC50:  907nMAssay Description:Antagonist activity at human recombinant TRPV1 assessed as inhibition of capsaicin-induced in intracellular calcium levels by cell-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed