BDBM50331555 CHEMBL1289305::N-(1-(1H-pyrazol-3-ylamino)-1,2-dioxopentan-3-yl)-2-chloro-3-(trifluoromethyl)benzamide

SMILES CCC(NC(=O)c1cccc(c1Cl)C(F)(F)F)C(=O)C(=O)Nc1ccn[nH]1

InChI Key InChIKey=VKQOQWWJCCFELL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50331555   

TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(CHEMBL1289305 | N-(1-(1H-pyrazol-3-ylamino)-1,2-di...)
Affinity DataIC50:  5.75E+3nMAssay Description:Inhibition of human cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(CHEMBL1289305 | N-(1-(1H-pyrazol-3-ylamino)-1,2-di...)
Affinity DataIC50:  891nMAssay Description:Inhibition of human cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(CHEMBL1289305 | N-(1-(1H-pyrazol-3-ylamino)-1,2-di...)
Affinity DataIC50:  11.7nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(CHEMBL1289305 | N-(1-(1H-pyrazol-3-ylamino)-1,2-di...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as Lip10 accumulation by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(CHEMBL1289305 | N-(1-(1H-pyrazol-3-ylamino)-1,2-di...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(CHEMBL1289305 | N-(1-(1H-pyrazol-3-ylamino)-1,2-di...)
Affinity DataIC50:  29.5nMAssay Description:Inhibition of human cathepsin V by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed