BDBM50331776 (S)-4,4-dichloro-N-((S)-1-cyano-2-phenylethyl)-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)butanamide::CHEMBL1290084

SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N[C@@H](CC(Cl)Cl)C(=O)N[C@@H](Cc1ccccc1)C#N)C(F)(F)F

InChI Key InChIKey=UULSCOLFHVNVPK-GVUKDKGQSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50331776   

TargetCathepsin F(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331776((S)-4,4-dichloro-N-((S)-1-cyano-2-phenylethyl)-2-(...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human Cat F expressed in rabbit HIG82 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331776((S)-4,4-dichloro-N-((S)-1-cyano-2-phenylethyl)-2-(...)
Affinity DataIC50:  383nMAssay Description:Inhibition of human Cat B in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331776((S)-4,4-dichloro-N-((S)-1-cyano-2-phenylethyl)-2-(...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of trypanosoma cruzi CruzipainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331776((S)-4,4-dichloro-N-((S)-1-cyano-2-phenylethyl)-2-(...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human Cat LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed