BDBM50332012 CHEMBL1290790::N-(5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-3-yl)benzenesulfonamide

SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cncc(NS(=O)(=O)c2ccccc2)c1

InChI Key InChIKey=UNMOFIMYKFXMJC-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50332012   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332012(CHEMBL1290790 | N-(5-(3-(3,4-dimethoxyphenyl)-1H-p...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332012(CHEMBL1290790 | N-(5-(3-(3,4-dimethoxyphenyl)-1H-p...)
Affinity DataIC50:  346nMAssay Description:Inhibition of c-KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332012(CHEMBL1290790 | N-(5-(3-(3,4-dimethoxyphenyl)-1H-p...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332012(CHEMBL1290790 | N-(5-(3-(3,4-dimethoxyphenyl)-1H-p...)
Affinity DataKd:  48nMAssay Description:Binding affinity to PI3Kalpha by high throughput assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology (Kaist)

Curated by ChEMBL
LigandPNGBDBM50332012(CHEMBL1290790 | N-(5-(3-(3,4-dimethoxyphenyl)-1H-p...)
Affinity DataKd:  145nMAssay Description:Binding affinity to TRKA by high throughput assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed