BDBM50332300 4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)benzoic acid::CHEMBL1287941

SMILES Nc1nc(Nc2ccc(cc2)C(O)=O)nn1C(=O)c1c(F)cccc1F

InChI Key InChIKey=LTYMDXLXKVBMED-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50332300   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  2.11E+3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed