BDBM503324 2-[3a-(aminomethyl)-octahydro-1H- isoindol-2-yl]-6-amino-5-(2,3- dichlorophenyl)-pyrimidine-4- carboxamide::US11033547, Compound 24::US11696916, Compound 24

SMILES NCC12CN(CC1CCCC2)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O

InChI Key InChIKey=IKMGLAPRJVWUEO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503324   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503324(2-[3a-(aminomethyl)-octahydro-1H- isoindol-2-yl]-6...)
Affinity DataIC50:  270nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503324(2-[3a-(aminomethyl)-octahydro-1H- isoindol-2-yl]-6...)
Affinity DataIC50:  270nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent