BDBM50333372 5-((4-aminopiperidin-1-yl)methyl)-N-(3-chloro-4-fluorophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine::CHEMBL1645476

SMILES NC1CCN(Cc2ccn3ncnc(Nc4ccc(F)c(Cl)c4)c23)CC1

InChI Key InChIKey=CGRLNCABNBKKKW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50333372   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50333372(5-((4-aminopiperidin-1-yl)methyl)-N-(3-chloro-4-fl...)
Affinity DataIC50:  370nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50333372(5-((4-aminopiperidin-1-yl)methyl)-N-(3-chloro-4-fl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50333372(5-((4-aminopiperidin-1-yl)methyl)-N-(3-chloro-4-fl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50333372(5-((4-aminopiperidin-1-yl)methyl)-N-(3-chloro-4-fl...)
Affinity DataIC50:  110nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed