BDBM50335097 6-(methylsulfonyl)benzo[d]thiazol-2-amine::6-Methanesulfonyl-benzothiazol-2-ylamine::CHEMBL432942

SMILES CS(=O)(=O)c1ccc2nc(N)sc2c1

InChI Key InChIKey=ZYHNHJAMVNINSY-UHFFFAOYSA-N

Data  1 KI  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50335097   

TargetPteridine reductase 1(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of Leishmania major PTR1 by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataIC50:  1.79E+6nMAssay Description:Inhibition of Leishmania major DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataIC50:  1.04E+6nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Modena And Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP2C9 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Modena And Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP2D6 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Modena And Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP3A4 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase 1(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataIC50:  3.29E+4nMAssay Description:Inhibition of Leishmania major pteridine reductase 1 using di-hydrobiopterine as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Modena And Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataIC50: >2.50E+4nMAssay Description:Displacement of Tracer Red from human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Modena And Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP1A2 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase 1(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataIC50:  2.12E+5nMAssay Description:Inhibition of Leishmania major PTR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Modena And Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50335097(6-(methylsulfonyl)benzo[d]thiazol-2-amine | 6-Meth...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human CYP2C19 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed