BDBM50335242 3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yloxy)methyl)biphenyl-4-carboxylic Acid::CHEMBL1651219

SMILES OC(=O)c1cc(ccc1Cl)-c1cccc(COc2ccc3c(c2)sn(C2CCCC2)c3=O)c1

InChI Key InChIKey=ZQBPXBADOJMCRU-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50335242   

TargetD(1A) dopamine receptor(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of radioligand binding to human dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataEC50:  170nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK-293 cells assessed as thaillium flux through GIRK channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataEC50:  170nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of radioligand binding to human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed