BDBM50335255 3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yloxy)methyl)-biphenyl-4-carboxylic acid::3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yloxy)methyl)biphenyl-4-carboxylic acid::CHEMBL593013

SMILES Cc1c2C(=O)C(Cc2cc(OCc2cccc(c2)-c2ccc(cc2)C(O)=O)c1C)C1CCCC1

InChI Key InChIKey=KMKBEESNZAPKMP-UHFFFAOYSA-N

Data  1 KI  1 Kd  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50335255   

TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by liquid scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  27.5nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  380nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataKd:  190nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  93nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  441nMAssay Description:Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293A cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  380nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK-293 cells assessed as thaillium flux through GIRK channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed