BDBM50336457 (3S,5Z,8S,9R,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione::CHEMBL1077979::CHEMBL1668411::CHEMBL1801950
SMILES COc1cc(O)c2c(CCCC(=O)C(=O)C(=O)CCC[C@H](C)OC2=O)c1
InChI Key InChIKey=AYXFORKQNMKTGL-NSHDSACASA-N
Data 19 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50336457
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant VEGFR3 in cell free system after 90 minsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Covalution Pharma
Curated by ChEMBL
Covalution Pharma
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of MKK4More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant ERK1 expressed in E.coli after 30 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant VEGFR1 expressed in Sf9 cells after 10 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant ERK5 in cell free system after 90 minsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant PDGFRbeta expressed in insect cells after 30 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant ERK2 expressed in E.coli after 15 minsMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 9.60nMAssay Description:Inhibition of human recombinant c-kit kinase in cell free system after 30 minsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human recombinant PDGFRalpha in cell free system after 60 minsMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant GSK3alpha in cell free system after 60 minsMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human recombinant GSK3-beta in cell free system after 90 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human recombinant VEGFR2 expressed in Sf9 cells after 60 minsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant MEK1 expressed in insect cells after 20 minsMore data for this Ligand-Target Pair
TargetTranscription factor p65(Homo sapiens (Human))
University Of North Carolina At Greensboro
Curated by ChEMBL
University Of North Carolina At Greensboro
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISAMore data for this Ligand-Target Pair
TargetTranscription factor p65(Homo sapiens (Human))
University Of North Carolina At Greensboro
Curated by ChEMBL
University Of North Carolina At Greensboro
Curated by ChEMBL
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Covalution Pharma
Curated by ChEMBL
Covalution Pharma
Curated by ChEMBL
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National University Of Ireland
Curated by ChEMBL
National University Of Ireland
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human recombinant FLT-3 kinase expressed in insect cells after 90 minsMore data for this Ligand-Target Pair