BDBM50336761 5-[4-(2-Trifluoromethylphenoxy)-3-methoxybenzylidene]-thiazolidine-2,4-dione::CHEMBL1671972

SMILES COc1cc(C=C2SC(O)=NC2=O)ccc1Oc1ccccc1C(F)(F)F

InChI Key InChIKey=DTWGKFUSEYNFHI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50336761   

TargetSteroid hormone receptor ERR1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50336761(5-[4-(2-Trifluoromethylphenoxy)-3-methoxybenzylide...)
Affinity DataIC50:  68nMAssay Description:Antagonist activity at 6his-tagged ERRalpha LBD assessed as inhibition of recruitment of GST-labeled coactivator Scr2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50336761(5-[4-(2-Trifluoromethylphenoxy)-3-methoxybenzylide...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50336761(5-[4-(2-Trifluoromethylphenoxy)-3-methoxybenzylide...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid hormone receptor ERR1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50336761(5-[4-(2-Trifluoromethylphenoxy)-3-methoxybenzylide...)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at ERRalpha LBD expressed in HEK293 cells assessed as Gal4-SRC2 interaction by two hybrid luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed