BDBM50336879 2-morpholino-4,5'-bipyrimidin-2'-amine::CHEMBL1672331

SMILES Nc1ncc(cn1)-c1ccnc(n1)N1CCOCC1

InChI Key InChIKey=WCSNDONKXWSCEI-UHFFFAOYSA-N

Data  3 KI  1 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50336879   

LigandPNGBDBM50336879(2-morpholino-4,5'-bipyrimidin-2'-amine | CHEMBL167...)
Affinity DataKi:  0.640nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
LigandPNGBDBM50336879(2-morpholino-4,5'-bipyrimidin-2'-amine | CHEMBL167...)
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336879(2-morpholino-4,5'-bipyrimidin-2'-amine | CHEMBL167...)
Affinity DataKi:  81nMAssay Description:Inhibition of recombinant human PI3K p110delta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336879(2-morpholino-4,5'-bipyrimidin-2'-amine | CHEMBL167...)
Affinity DataEC50:  130nMAssay Description:Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hrMore data for this Ligand-Target Pair
LigandPNGBDBM50336879(2-morpholino-4,5'-bipyrimidin-2'-amine | CHEMBL167...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kalpha after 15 minsMore data for this Ligand-Target Pair