BDBM50336976 CHEMBL1672622::N-(5,6-Dipyridin-4-ylpyrazin-2-yl)cyclopropanecarboxamide

SMILES O=C(Nc1cnc(-c2ccncc2)c(n1)-c1ccncc1)C1CC1

InChI Key InChIKey=YAPJZGXRIHUBAY-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50336976   

TargetAdenosine receptor A2b(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336976(CHEMBL1672622 | N-(5,6-Dipyridin-4-ylpyrazin-2-yl)...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336976(CHEMBL1672622 | N-(5,6-Dipyridin-4-ylpyrazin-2-yl)...)
Affinity DataKi:  312nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HeLa cells after 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336976(CHEMBL1672622 | N-(5,6-Dipyridin-4-ylpyrazin-2-yl)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336976(CHEMBL1672622 | N-(5,6-Dipyridin-4-ylpyrazin-2-yl)...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336976(CHEMBL1672622 | N-(5,6-Dipyridin-4-ylpyrazin-2-yl)...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336976(CHEMBL1672622 | N-(5,6-Dipyridin-4-ylpyrazin-2-yl)...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed