BDBM503379 2-(4-Amino-4-methyl-piperidin-1- yl)-5-(2,3-dichloro-pyridin-4-yl)-6- methyl-pyrimidine-4-carboxylic acid amide::US11033547, Compound 81::US11696916, Compound 81

SMILES Cc1nc(nc(C(N)=O)c1-c1ccnc(Cl)c1Cl)N1CCC(C)(N)CC1

InChI Key InChIKey=HUMIECSLNOZHDL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503379   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503379(2-(4-Amino-4-methyl-piperidin-1- yl)-5-(2,3-dichlo...)
Affinity DataIC50:  720nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503379(2-(4-Amino-4-methyl-piperidin-1- yl)-5-(2,3-dichlo...)
Affinity DataIC50:  720nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent