BDBM50338324 (+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol::CHEMBL1682441
SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2cc[nH]c12
InChI Key InChIKey=KEOBSGVCNPPEQR-APBUJDDRSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50338324
Affinity DataKi: 2.5nMAssay Description:Displacement of radiolabeled dexamethasone from GRMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of radiolabeled dexamethasone from GRMore data for this Ligand-Target Pair
Affinity DataKi: 1.43E+3nMAssay Description:Binding affinity to ARMore data for this Ligand-Target Pair
Affinity DataKi: 1.52E+3nMAssay Description:Binding affinity to mineralocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.52E+3nMAssay Description:Binding affinity to MRMore data for this Ligand-Target Pair
Affinity DataKi: 2.10E+3nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.10E+3nMAssay Description:Binding affinity to PRMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasoneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...More data for this Ligand-Target Pair
Affinity DataEC50: 53nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with PEPCK assessed as GRE activation by luciferase reporter gene ass...More data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as GRE activation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Transrepression activity at glucocorticoid receptor in human NHDF cells assessed as inhibition of IL-1beta-stimulated AP1 dependent IL-6 repression b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Transrepression activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin...More data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...More data for this Ligand-Target Pair
Affinity DataEC50: 98nMAssay Description:Agonist activity at GR expressed in rat H4IIEC3 cells assessed as induction of PEPCK transactivation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Transrepression activity at GR expressed in NHDF cells assessed as IL-1beta-mediated IL-6 transcription by ELISAMore data for this Ligand-Target Pair