BDBM50339081 6-[Ethyl-(3-isobutoxy-4-isopropylphenyl)amino]nicotinic acid::CHEMBL1688383

SMILES CCN(c1ccc(C(C)C)c(OCC(C)C)c1)c1ccc(cn1)C(O)=O

InChI Key InChIKey=JUCWZKDTWSKUAW-UHFFFAOYSA-N

Data  2 KI  1 IC50  2 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50339081   

TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50339081(6-[Ethyl-(3-isobutoxy-4-isopropylphenyl)amino]nico...)
Affinity DataKi:  182nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50339081(6-[Ethyl-(3-isobutoxy-4-isopropylphenyl)amino]nico...)
Affinity DataKi:  182nMAssay Description:Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50339081(6-[Ethyl-(3-isobutoxy-4-isopropylphenyl)amino]nico...)
Affinity DataKd:  340nMAssay Description:Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant using PGC-1al...More data for this Ligand-Target Pair
LigandPNGBDBM50339081(6-[Ethyl-(3-isobutoxy-4-isopropylphenyl)amino]nico...)
Affinity DataIC50:  394nMAssay Description:Displacement of CU-6PMN from human PPARgamma-LBD (206 to 477 residues)/human RXRalpha-LBD (224 to 462 residues) heterodimer incubated for 30 mins by ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50339081(6-[Ethyl-(3-isobutoxy-4-isopropylphenyl)amino]nico...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant using SRC1 as...More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50339081(6-[Ethyl-(3-isobutoxy-4-isopropylphenyl)amino]nico...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at RXRalpha transfected in human COS1 cells after 18 hrs by luciferase reporter gene transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50339081(6-[Ethyl-(3-isobutoxy-4-isopropylphenyl)amino]nico...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at RXRalpha (unknown origin) expressed in COS1 cells incubated for 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair