BDBM50339352 (+/-)-cis-3-(4-Chlorophenyl)-3-(4-hydroxycyclopent-2-enyloxy)-2-(4-nitrobenzyl)isoindolin-1-one::CHEMBL1688257::US8618158, NU8297

SMILES O[C@H]1C[C@@H](OC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)C=C1

InChI Key InChIKey=DQNTZPIUUCMFMC-SGNGHUOJSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50339352   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50339352((+/-)-cis-3-(4-Chlorophenyl)-3-(4-hydroxycyclopent...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50339352((+/-)-cis-3-(4-Chlorophenyl)-3-(4-hydroxycyclopent...)
Affinity DataIC50:  1.40E+3nMT: 2°CAssay Description:Streptavidin-coated 96-well plates are used to immobilise a biotin-tagged IP3 p53-derived peptide (MPRFMDYWEGLN). This is a peptide analogue derived ...More data for this Ligand-Target Pair
In DepthDetails US Patent