BDBM50339392 (+/-)-3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(pyridin-2-ylmethyl)isoindolin-1-one::CHEMBL1688297::US8618158, NU8429

SMILES OCC1(COC2(N(Cc3ccccn3)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=WTTYGKVLWTWCGK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50339392   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50339392((+/-)-3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cycl...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50339392((+/-)-3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cycl...)
Affinity DataIC50:  1.06E+4nMT: 2°CAssay Description:Streptavidin-coated 96-well plates are used to immobilise a biotin-tagged IP3 p53-derived peptide (MPRFMDYWEGLN). This is a peptide analogue derived ...More data for this Ligand-Target Pair
In DepthDetails US Patent