BDBM50340014 4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triazol-3-yl)methyl)-6-(trifluoromethyl)-2H-benzo[b][1,4]thiazin-3(4H)-one::CHEMBL1762483

SMILES Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1

InChI Key InChIKey=XCSRSXRUZPDJHS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340014   

TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340014(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340014(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSGLT1 protein(Mus musculus (Mouse))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340014(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of mouse SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Rattus norvegicus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340014(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of rat SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Mus musculus (Mouse))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340014(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of mouse SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Rattus norvegicus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340014(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Affinity DataIC50:  400nMAssay Description:Inhibition of rat SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed