BDBM50341309 CHEMBL1766081::isopropyl 4-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)piperidine-1-carboxylate

SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cccnc2C)c1C

InChI Key InChIKey=YHKUMVXEUWUPKX-UHFFFAOYSA-N

Data  2 KI  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50341309   

TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50341309(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50341309(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50341309(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Affinity DataEC50:  84nMAssay Description:Agonist activity at rat GPR119 expressed in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50341309(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50341309(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cMAP level by cell-based cAMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50341309(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Affinity DataEC50:  83nMAssay Description:Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50341309(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at GPR119 in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed