BDBM503414 (5P)-6-amino-2-[(1S)-1-amino-1,3- dihydrospiro[indene-2,4'-piperidin]-1'- yl]-5-(2,3-dichlorophenyl)pyrimidine-4- carboxamide::US11033547, Compound 117

SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1nc(N)c(C2=C(Cl)C(Cl)=CCC2)c(n1)C(N)=O

InChI Key InChIKey=RJDPMRRAPDZDTF-HXUWFJFHSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 503414   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503414((5P)-6-amino-2-[(1S)-1-amino-1,3- dihydrospiro[ind...)
Affinity DataIC50:  1nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent