BDBM50341727 3-amino-6-(3-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide::CHEMBL1766773::US10479784, Compound I-3::US10961232, Compound I-3

SMILES CS(=O)(=O)c1cccc(c1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1

InChI Key InChIKey=ISWAJEMQAQNLMY-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50341727   

TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50341727(3-amino-6-(3-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataKi:  2.55E+3nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50341727(3-amino-6-(3-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataKi:  5.05E+3nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50341727(3-amino-6-(3-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50:  340nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341727(3-amino-6-(3-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50:  740nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341727(3-amino-6-(3-(methylsulfonyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed