BDBM50341760 2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid{6-[(2-Methoxyethyl)methylamino]pyridin-3-yl}amide::CHEMBL1766813

SMILES COCCN(C)c1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cn1

InChI Key InChIKey=QEZWDFXCTTZZRI-UHFFFAOYSA-N

Data  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50341760   

TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341760(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataEC50:  661nMAssay Description:Inhibition of human DGAT1 expressed in CHO-K1 cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341760(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected insect cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341760(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataEC50:  660nMAssay Description:Inhibition of human DGAT1 expressed in CHO-K1 cells after 1 hr using [14C]palmitic acid by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341760(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human DGAT1 expressed in Sf9 cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-Co A substrates incubated for 2 hrs by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341760(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human DGAT1 using palmitoyl-1-14C coenzyme A and DAG as substrate after 1 hr by phospholipid flash plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341760(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataEC50:  660nMAssay Description:Inhibition of human DGAT1 expressed in CHOK1 cells using 14C palmitic acid as substrate after 1 hr by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Rattus norvegicus (rat))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50341760(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataIC50:  120nMAssay Description:Inhibition of rat DGAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341760(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human DGAT1 using [14C]palmitic acid by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed