BDBM50341814 (1S,2R,3R)-1-[(R)-4-(5-Cyanothiophen-2-yl)-3-methylpiperazine-1-sulfonylamino]-2,3-dimethyl-2-phenylcyclopropanecarboxylicAcid::CHEMBL1767016

SMILES C[C@@H]1[C@](C)(c2ccccc2)[C@]1(NS(=O)(=O)N1CCN([C@H](C)C1)c1ccc(s1)C#N)C(O)=O

InChI Key InChIKey=HOFOGNHCTQAGAM-AHWCRGGASA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341814   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341814((1S,2R,3R)-1-[(R)-4-(5-Cyanothiophen-2-yl)-3-methy...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341814((1S,2R,3R)-1-[(R)-4-(5-Cyanothiophen-2-yl)-3-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant TACE after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341814((1S,2R,3R)-1-[(R)-4-(5-Cyanothiophen-2-yl)-3-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP1 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341814((1S,2R,3R)-1-[(R)-4-(5-Cyanothiophen-2-yl)-3-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed