BDBM50342276 (2-Ethyl-5-hydroxybenzofuran-3-yl)(4-hydroxyphenyl)methanone::CHEMBL1767090::US9725430, Compound 1j::US9962362, Compound 1j

SMILES CCc1oc2ccc(O)cc2c1C(=O)c1ccc(O)cc1

InChI Key InChIKey=CGUSGHJDNCSDGH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342276   

TargetSolute carrier family 22 member 12(Homo sapiens (Human))
University Of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342276((2-Ethyl-5-hydroxybenzofuran-3-yl)(4-hydroxyphenyl...)
Affinity DataIC50:  2.49E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEyes absent homolog 3(Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50342276((2-Ethyl-5-hydroxybenzofuran-3-yl)(4-hydroxyphenyl...)
Affinity DataIC50:  7.31E+4nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEyes absent homolog 3(Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50342276((2-Ethyl-5-hydroxybenzofuran-3-yl)(4-hydroxyphenyl...)
Affinity DataIC50:  7.31E+4nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
In DepthDetails US Patent