BDBM50342460 (S)-cyclobutyl(2-(3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone::CHEMBL1771677

SMILES COc1cccc(c1)-c1noc(n1)[C@@H]1CCCCN1C(=O)C1CCC1

InChI Key InChIKey=MBAGGIFLYQBGOQ-INIZCTEOSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342460   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342460((S)-cyclobutyl(2-(3-(3-methoxyphenyl)-1,2,4-oxadia...)
Affinity DataKi:  182nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342460((S)-cyclobutyl(2-(3-(3-methoxyphenyl)-1,2,4-oxadia...)
Affinity DataIC50:  501nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50342460((S)-cyclobutyl(2-(3-(3-methoxyphenyl)-1,2,4-oxadia...)
Affinity DataIC50:  80nMAssay Description:Negative allosteric modulator activity at mGluR5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium flux preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed