BDBM50342910 6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4-yl)methyl)quinazolin-4-amine::CHEMBL1435542

SMILES Cc1nc(CNc2ncnc3ccc(cc23)-c2ccc3OCOc3c2)cs1

InChI Key InChIKey=LELRIWOVACJYND-UHFFFAOYSA-N

Data  6 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50342910   

TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of Clk2 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataIC50:  1.51E+3nMAssay Description:Inhibition of Dyrk1B kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataIC50:  7.45E+3nMAssay Description:Inhibition of Clk3 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataKd:  280nMAssay Description:Binding affinity to human PIP5K2C More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataKd:  380nMAssay Description:Binding affinity to human Clk2 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataIC50:  206nMAssay Description:Inhibition of Dyrk1A kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataKd:  43nMAssay Description:Binding affinity to human Clk4 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataKd:  50nMAssay Description:Binding affinity to human Clk1 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataKd:  82nMAssay Description:Binding affinity to human Dyrk1A More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataIC50:  96nMAssay Description:Inhibition of Clk1 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50342910(6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Clk4 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed