BDBM50343088 CHEMBL1771223::N-hydroxy-4-(4-(3-(1-(4-(trifluoromethoxy)phenyl)-1H-tetrazol-5-yl)propoxy)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide

SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(OCCCc2nnnn2-c2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=UAFRGDNTZQMZFA-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50343088   

TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(CHEMBL1771223 | N-hydroxy-4-(4-(3-(1-(4-(trifluoro...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(CHEMBL1771223 | N-hydroxy-4-(4-(3-(1-(4-(trifluoro...)
Affinity DataKi:  9.90nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(CHEMBL1771223 | N-hydroxy-4-(4-(3-(1-(4-(trifluoro...)
Affinity DataKi:  72nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(CHEMBL1771223 | N-hydroxy-4-(4-(3-(1-(4-(trifluoro...)
Affinity DataKi:  430nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(CHEMBL1771223 | N-hydroxy-4-(4-(3-(1-(4-(trifluoro...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(CHEMBL1771223 | N-hydroxy-4-(4-(3-(1-(4-(trifluoro...)
Affinity DataKi:  7.10E+3nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(CHEMBL1771223 | N-hydroxy-4-(4-(3-(1-(4-(trifluoro...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(CHEMBL1771223 | N-hydroxy-4-(4-(3-(1-(4-(trifluoro...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed