BDBM50343299 2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-methyl-1H-benzo-[d]imidazole::2-((4-(2-fluorophenyl)piperidin-1-yl)methyl)-1-methyl-1H-benzo[d]imidazole::CHEMBL607689

SMILES Cn1c(CN2CCC(CC2)c2ccccc2F)nc2ccccc12

InChI Key InChIKey=AMADNKXMEDYTCS-UHFFFAOYSA-N

Data  3 KI  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50343299   

TargetD(2) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity at human D2 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  100nMAssay Description:Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Agonist activity at mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50:  130nMAssay Description:Positive allosteric modulation of human mGlu2 receptor stably expressed in human Chem-1 cells assessed as potentiation of glutamate-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Positive modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50:  126nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50:  3.98E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Antagonist activity at mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Agonist activity at mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50:  22nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Antagonist activity at mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed