BDBM50343321 CHEMBL1774229::cis-2-(((3R,4R)-4-(4-chloro-2-fluorophenyl)-3-methylpiperidin-1-yl)methyl)-1-methyl-1H-imidazo[4,5-b]pyridine

SMILES C[C@H]1CN(Cc2nc3ncccc3n2C)CC[C@H]1c1ccc(Cl)cc1F

InChI Key InChIKey=HUDWYYYFRVUKIA-DZGCQCFKSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50343321   

TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343321(CHEMBL1774229 | cis-2-(((3R,4R)-4-(4-chloro-2-fluo...)
Affinity DataKi:  1.62E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343321(CHEMBL1774229 | cis-2-(((3R,4R)-4-(4-chloro-2-fluo...)
Affinity DataEC50:  28nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed