BDBM50343759 1-ethyl-3-(4-(6-(2-hydroxypropan-2-yl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenyl)urea::CHEMBL1774349

SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2sc(cc2n1)C(C)(C)O

InChI Key InChIKey=SZCIVAGLLOHSLG-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343759   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50343759(1-ethyl-3-(4-(6-(2-hydroxypropan-2-yl)-4-morpholin...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant mTOR expressed in insect cells using 4E-BP1 substrate after 30 mins by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50343759(1-ethyl-3-(4-(6-(2-hydroxypropan-2-yl)-4-morpholin...)
Affinity DataKi:  3nMAssay Description:Inhibition of human N-terminal FLAG-tagged mTOR (1362-end residues) in presence of [gamma33P]ATP after 40 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50343759(1-ethyl-3-(4-(6-(2-hydroxypropan-2-yl)-4-morpholin...)
Affinity DataKi:  3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed