BDBM50343795 CHEMBL1774538::N-(3-Fluoro-4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-benzo[b]thiophene-2-carboxamide

SMILES COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3s2)CC1

InChI Key InChIKey=DSOWHOSHPUSGFM-UHFFFAOYSA-N

Data  4 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50343795   

TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343795(CHEMBL1774538 | N-(3-Fluoro-4-(4-(2-methoxyphenyl)...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [125I]-IABN from human dopamine D3 receptor expressed in HEK293 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343795(CHEMBL1774538 | N-(3-Fluoro-4-(4-(2-methoxyphenyl)...)
Affinity DataKi:  139nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343795(CHEMBL1774538 | N-(3-Fluoro-4-(4-(2-methoxyphenyl)...)
Affinity DataKi:  241nMAssay Description:Displacement of [125I]-IABN from human dopamine D2L receptor expressed in HEK293 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343795(CHEMBL1774538 | N-(3-Fluoro-4-(4-(2-methoxyphenyl)...)
Affinity DataKi:  3.03E+3nMAssay Description:Displacement of [125I]DOI from 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343795(CHEMBL1774538 | N-(3-Fluoro-4-(4-(2-methoxyphenyl)...)
Affinity DataEC50:  440nMAssay Description:Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343795(CHEMBL1774538 | N-(3-Fluoro-4-(4-(2-methoxyphenyl)...)
Affinity DataIC50:  3.21E+3nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343795(CHEMBL1774538 | N-(3-Fluoro-4-(4-(2-methoxyphenyl)...)
Affinity DataIC50:  83nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343795(CHEMBL1774538 | N-(3-Fluoro-4-(4-(2-methoxyphenyl)...)
Affinity DataIC50:  421nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed