BDBM50344071 CHEMBL1777864::rac-3-(4-(4-cyanonaphthalen-1-yloxy)phenyl)hex-4-ynoic acid

SMILES CC#CC(CC(O)=O)c1ccc(Oc2ccc(C#N)c3ccccc23)cc1

InChI Key InChIKey=XXLJKNIPVFEZHE-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50344071   

TargetFree fatty acid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344071(CHEMBL1777864 | rac-3-(4-(4-cyanonaphthalen-1-ylox...)
Affinity DataEC50:  247nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 0.4% serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344071(CHEMBL1777864 | rac-3-(4-(4-cyanonaphthalen-1-ylox...)
Affinity DataEC50:  53nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344071(CHEMBL1777864 | rac-3-(4-(4-cyanonaphthalen-1-ylox...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344071(CHEMBL1777864 | rac-3-(4-(4-cyanonaphthalen-1-ylox...)
Affinity DataEC50:  93nMAssay Description:Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344071(CHEMBL1777864 | rac-3-(4-(4-cyanonaphthalen-1-ylox...)
Affinity DataEC50:  172nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as [3H]IP3 production in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed