BDBM50344232 1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyrazin-2-yl)methyl)methanamine::CHEMBL1778865
SMILES COc1cc(F)ccc1-c1cncc(CNCC2CC2)n1
InChI Key InChIKey=YICPRNFRCVOHKV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50344232
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals
Curated by ChEMBL
Astrazeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Astrazeneca Pharmaceuticals
Curated by ChEMBL
Astrazeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 508nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells assessed as glutamate-induced changes in intracellular calcium concentrationMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals
Curated by ChEMBL
Astrazeneca Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells electrophysiology studyMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Iinhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Iinhibition of CYP3A4More data for this Ligand-Target Pair