BDBM50345712 3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL1231372::CHEMBL2069314::US10544104, Compound 5h::US11247972, Compound 5h::US9765037, Compound 5h

SMILES Nc1ncnc2n(CC3CCNCC3)nc(Cc3cccc4ccccc34)c12

InChI Key InChIKey=MMRLNUFECMEMSQ-UHFFFAOYSA-N

Data  20 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50345712   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Toxoplasma gondii recombinant N-terminal hexahistidine tagged CDPK1 expressed in Escherichia coli using syntide-2 as substrate after 90...More data for this Ligand-Target Pair
TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  9nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  15nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  9nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  9nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  9nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  9nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent protein kinase()
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  15nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent protein kinase()
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphorimaging methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed